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February 2, 2026BMC Immunology1 citationsOpen Access

The correlation between the systemic immune-inflammation index and relapse and metastasis in cervical squamous cell carcinoma patients over 50 years and older

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YJYanjun JiaoYHYang HeBZBinyan Zhao

Key Points

  • To investigate the relationship between systemic immune-inflammation index (SII) and cancer relapse and metastasis in patients over 50 with cervical squamous cell carcinoma (CSCC).
  • Analyzed levels of systemic immune-inflammation index (SII) in cervical squamous cell carcinoma patients aged 50 and older.
  • Monitored and recorded incidences of relapse and metastasis among these patients.
  • Higher systemic immune-inflammation index (SII) levels correlate with a significantly increased risk of cancer relapse.
  • Patients with elevated SII show a greater likelihood of metastasis, indicating poorer prognosis.

Abstract

Higher levels of SII are significantly associated with a higher risk of relapse and metastasis, indicating that SII may have important clinical value in the prognosis assessment of CSCC.

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Cite This Study

Jiao et al. (2026) studied this question.

synapsesocial.com/papers/6980fcb6c1c9540dea80e834https://doi.org/10.1186/s12865-025-00791-8
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