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February 2, 2026Hematology2 citationsOpen Access

Improvement in anemia and symptoms after switching from crovalimab to iptacopan in paroxysmal nocturnal hemoglobinuria

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DODaisuke OgiyaSSSawako ShiraiwaSKSeina Koyama

Key Points

  • This study aims to evaluate the effects of switching from crovalimab to iptacopan on anemia and symptoms in patients with paroxysmal nocturnal hemoglobinuria.
  • Evaluate clinical outcomes after switching treatments
  • Assess anemia levels and symptom improvement
  • Focus on patients inadequately controlled with C5 inhibitors
  • Rapid improvement in anemia was observed after the switch
  • Symptoms associated with paroxysmal nocturnal hemoglobinuria showed durable improvement
  • Proximal complement inhibition was supported as an effective treatment strategy

Abstract

Switching to iptacopan led to rapid and durable improvement in anemia and symptoms, supporting proximal complement inhibition as a valuable option for PNH patients inadequately controlled with C5 inhibitors.

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Cite This Study

Ogiya et al. (2026) studied this question.

synapsesocial.com/papers/6980fd9dc1c9540dea80f544https://doi.org/10.1080/16078454.2026.2620152
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