Background: Decreased Ovarian Reserve (DOR) is a significant challenge in infertility treatment. This study, which compared the effects of Novel Dual Trigger and Delayed Human Chorionic Gonadotropin (HCG), holds promise for improving IVF outcomes. Materials and Methods: This was a randomized, double-blinded clinical trial on 90 infertile women. An antagonist regimen was used, which included approximately 300 units of gonadotropins, consisting of 150 units of Human menopausal gonadotropin (hMG) and 150 units of Synal-F. After administering a dose of Strotide injection followed by Decapeptyl and Ovitrelle injections, 12 hours later, a single HCG 5000-unit injection was administered, and 36 hours later, the puncture procedure was performed. Results: Although the frequency of chemical pregnancy, Implantation rate, and ongoing pregnancy was higher in the Novel double trigger with delayed HCG group, and the frequency of zero oocytes and fetus was lower in this group, this difference was not statistically significant. Conclusion: This study showed that using Novel Dual Trigger and Delayed HCG, compared to Dual Trigger, did not significantly differ in the number of oocytes, embryos, or secondary pregnancy outcomes. These findings suggest that the Novel Dual Trigger and Delayed HCG methods could be equally effective in improving IVF outcomes for poor responder patients, providing a potential alternative for ovarian stimulation in these cases and instilling optimism for the future of IVF treatments.
Naghshineh et al. (2026) studied this question.