Reduced ejection fraction (<40%) was associated with significantly lower right ventricular four-chamber longitudinal strain compared to preserved ejection fraction (10.5% vs 18.1%; P=0.001).
Observational (n=87)
No
Right ventricular longitudinal systolic deformation significantly worsens in parallel with decreasing ejection fraction in patients with ischemic heart disease and chronic heart failure.
Absolute Event Rate: 10.5% vs 18.1%
p-value: p=0.001
Abstract Introduction Understanding the pathogenetic mechanisms of chronic heart failure (CHF) development, particularly the interrelation between right and left ventricular function, allows for the creation of more effective diagnostic strategies aimed at preventing disease progression. Purpose To assess the role of right ventricular deformation parameters in the progression of chronic heart failure in patients with ischemic heart disease. Materials and Methods The study included 87 patients hospitalized at our Medical Center of Cardiology with ischemic heart disease and chronic heart failure of functional class II, III, and IV, representing various CHF phenotypes. The following right ventricular systolic deformation parameters were analyzed: RVFWLS — longitudinal strain of the right ventricular free wall; RV4CLS — four-chamber longitudinal strain of the right ventricle. Results In the group with reduced ejection fraction (EF 40%), deformation parameters were the lowest: RVFWLS was 14.0 ± 4.1% and RV4CLS was 10.5 ± 3.1%. In the group with preserved ejection fraction (EF ≥ 50%), deformation values were higher: RVFWLS was 21.3 ± 4.0% and RV4CLS was 18.1 ± 3.2%. In the group with intermediate ejection fraction (EF 40–49%), deformation values were between these two groups: RVFWLS was 19.9 ± 2.8% and RV4CLS was 16.0 ± 2.7%. These intergroup differences were statistically significant, with a marked difference in the four-chamber longitudinal strain of the right ventricle (F=38.625, P=0.001 and F=65.366, P=0.001). Conclusion As the right ventricular ejection fraction decreases (transitioning from preserved to reduced EF), there is a significant deterioration in the longitudinal systolic deformation of the right ventricle, confirmed by statistically significant differences observed.
Bekmetova et al. (2026) conducted an observational in Ischemic heart disease and chronic heart failure (n=87). Reduced ejection fraction (<40%) vs. Preserved ejection fraction (≥50%) was evaluated on Right ventricular four-chamber longitudinal strain (RV4CLS) (p=0.001). Reduced ejection fraction (<40%) was associated with significantly lower right ventricular four-chamber longitudinal strain compared to preserved ejection fraction (10.5% vs 18.1%; P=0.001).