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February 2, 20260 citationsOpen Access

Improving Skin Lesion Detection with Transformer-Based Architectures

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AVAndrés Villamarín-OlmosDRDiego Renza

Key Points

  • To compare and improve the classification of skin lesions using various Transformer architectures.
  • Adjusted and compared eleven Transformer variants (five ViT and six Swin)
  • Employed hyperparameter tuning for model optimization
  • Utilized data augmentation to handle class imbalance
  • Analyzed results on DermaMNIST and ISIC Challenge 2019 datasets
  • Applied CheferCAM for visualizing influential image regions
  • Exceeds the performance of CNN-based models on the DermaMNIST dataset
  • Achieves competitive results against other Transformer models on ISIC Challenge 2019
  • Identified key image areas affecting model predictions using CheferCAM

Abstract

This article describes the methodology for adjusting and comparing eleven variants of Transformer architectures for the classification of skin lesions using images: five variants of Google’s Vision Transformer (ViT) and six variants of Microsoft’s Swin Transformer. We present the methodology used to achieve these results, which includes meticulous hyperparameter tuning and a robust data augmentation strategy to address the class imbalance problem. This approach allowed us to surpass the state of the art on the DermaMNIST dataset with respect to CNN-based models, and achieve very competitive results on the ISIC Challenge 2019 dataset with respect to Transformer-based models. In addition, we employed the CheferCAM method to provide visual explanations that identify the most influential image regions in the models’ predictions.

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Cite This Study

Villamarín-Olmos et al. (2026) studied this question.

synapsesocial.com/papers/6980ffb4c1c9540dea8126f5https://doi.org/10.3390/info17020130
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