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February 5, 2026Journal of Current Oncological Trends

Overlapping Transcriptomic Features between Autoimmune Liver Disease and Chronic Hepatitis B Highlight Inflammatory Signatures as Focal Points of Liver Disease Progression and HCC-associated Mortality

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Authors

SMSandipan MukherjeeAKArpita KarABAvik Biswas

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Overview

Transcriptomic analysis identifies inflammatory biomarkers for liver disease and HCC mortality.

Key Points

  • The research aims to identify overlapping transcriptomic biomarkers between autoimmune liver disease and chronic hepatitis B.
  • Analyzed transcriptomic datasets GSE159676 and GSE65359 for biomarker identification.
  • Used in silico analysis tools such as iDEP.92, STRING, Cytoscape, Enrichr, and KM-plotter.
  • Conducted in vitro validation with HCC cell lines and HBV-expressing plasmids.
  • Applied statistical analyses using two-tailed unpaired Student's t-test in GraphPad Prism.
  • Identified a positive transcriptomic correlation between autoimmune liver disease and the clearance phase of chronic hepatitis B.
  • CXCL8 was singled out as a reliable biomarker for therapeutic strategies targeting AILD and CHB.

Cite This Study

Mukherjee et al. (2025) studied this question.

synapsesocial.com/papers/698435e5f1d9ada3c1fb53bbhttps://doi.org/10.4103/jcot.jcot_7_25
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