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Synapse
February 6, 20260 citations

Phenotypic, Epidemiologic, and Imaging Features of Hypertrophic Cardiomyopathy: A Single-Center Experience.

GGG Babur GulerAGArda GülerİTİbrahim Halil Tanboğa

Key Result

Hypertrophic cardiomyopathy predominantly presented with obstructive and non-obstructive phenotypes, a notable genetic mutation burden, and low overall mortality primarily driven by heart failure.

Key Points

  • This research aims to explore the phenotypic and epidemiologic features of hypertrophic cardiomyopathy (HCM).
  • Analyzed a large regional cohort of HCM patients.
  • Identified obstructive and non-obstructive phenotypes.
  • Assessed the burden of genetic mutations and mortality outcomes.
  • Obstructive and non-obstructive phenotypes were predominantly observed.
  • The cohort exhibited a notable burden of genetic mutations.
  • Overall mortality rate was low, primarily due to heart failure.

Structured PICO

P
Population
701 patients aged 18 years and older with a confirmed diagnosis of hypertrophic cardiomyopathy (HCM) based on 2023 ESC guidelines, evaluated at a cardiomyopathy outpatient clinic of a tertiary referral center between October 2021 and November 2024. Median age 53.0 years, 68% male.

In a large regional cohort of HCM patients, obstructive and non-obstructive phenotypes predominated with a notable genetic mutation burden and low overall mortality primarily driven by heart failure.

Abstract

In this large regional cohort of HCM patients, obstructive and non-obstructive phenotypes were predominant, with a notable burden of genetic mutations and a low overall mortality rate primarily driven by heart failure. These findings emphasize the clinical heterogeneity of HCM and highlight the importance of comprehensive diagnostic evaluation.

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Cite This Study

Guler et al. (2026) studied this question. Hypertrophic cardiomyopathy predominantly presented with obstructive and non-obstructive phenotypes, a notable genetic mutation burden, and low overall mortality primarily driven by heart failure.

synapsesocial.com/papers/698585ea8f7c464f23009ae1https://doi.org/10.14744/anatoljcardiol.2025.5686
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Phenotypes and clinical outcomes of hypertrophic cardiomyopathy from a large cohort in Turkiye2026
  2. 2Echocardiographic diagnosis of the different phenotypes of hypertrophic cardiomyopathy2015 · 71 citations
  3. 3Multimodality Imaging in Hypertrophic Cardiomyopathy2026 · 1 citations
  4. 4PO26 Clinical Profiles and Outcomes of Genotype-Positive Hypertrophic Cardiomyopathy in an Ultraperipheral Region: A Decade of Experience2026
  5. 5Hypertrophic cardiomyopathy: A complex disease2018 · 16 citations