Non-valvular atrial fibrillation was associated with significantly lower cognitive function at 24 months compared to sinus rhythm (MoCA 24.2 vs 25.5, P<0.01), despite no difference in gray matter atrophy.
Observational (n=310)
Yes
Does non-valvular atrial fibrillation accelerate cognitive decline and brain atrophy compared to sinus rhythm in older adults?
In older patients with NVAF, cognitive decline over 24 months is significantly greater than in those with sinus rhythm, but this decline is not directly related to the extent of gray matter atrophy.
Absolute Event Rate: 24.2% vs 25.5%
p-value: p=<0.01
Abstract Background Cognitive function in patients with non-valvular atrial fibrillation (NVAF) tends to decline compared to patients without NVAF, even in the absence of symptomatic stroke or overt dementia. While previous studies have suggested an association between NVAF, and silent cerebral ischemia and microbleeds, the mechanisms linking NVAF to cognitive impairment remain unclear. Brain atrophy has been hypothesized as a potential contributor to cognitive dysfunction in NVAF patients, but its impact and clinical significance require further investigation. This study aimed to evaluate the relationship between brain atrophy and cognitive function in patients with NVAF. Methods The SKAF study is a prospective, investigator-initiated, multicenter, observational study involving Japanese patients with NVAF aged 60 years or older. We planned to enroll 200 NVAF patients with no history of symptomatic stroke or dementia, including those receiving anticoagulant therapy with edoxaban or not, and 100 patients with sinus rhythm for comparison. Participants underwent brain magnetic resonance imaging (MRI) and cognitive function assessment, including the Montreal Cognitive Assessment (MoCA), at enrollment and after 24 months. We analyzed cerebral atrophy using MRI. Results The study enrolled 310 patients (age: 72.1±6.5 years; male: 191 61.6%; NVAF: 213 68.7%). The mean CHA2DS2-VASc score in the NVAF group was 2.6±1.2. There was no significant difference between the NVAF group and the control group in the prevalence of silent ischemic stroke or silent microbleeds on MRI across the entire cohort. At enrollment, there was no significant difference in the MoCA score between the two groups (NVAF: 24.4±3.4, control: 25.2±2.9, P=0.054), and no difference in the extent of gray matter atrophy (NVAF: 3.5±1.6%, control: 3.4±2.1%, P=0.63). After 24 months, cognitive function in the NVAF group declined significantly compared to the control group (NVAF: 24.2±3.8, control: 25.5±3.2, P0.01), while the extent of gray matter atrophy in the NVAF group remained no different from that in the control group (NVAF: 3.9±2.7%, control: 3.7±2.0%, P=0.68). Conclusion The extent of gray matter atrophy was not directly related to cognitive function in patients with NVAF. These findings suggest that brain atrophy may not be the primary driver of cognitive decline in NVAF, and other factors, such as microvascular dysfunction or neuroinflammatory processes, may play a more significant role.
Chiba et al. (2025) conducted an observational in non-valvular atrial fibrillation (NVAF) (n=310). Non-valvular atrial fibrillation vs. Sinus rhythm was evaluated on Cognitive function (MoCA score) at 24 months (p=<0.01). Non-valvular atrial fibrillation was associated with significantly lower cognitive function at 24 months compared to sinus rhythm (MoCA 24.2 vs 25.5, P<0.01), despite no difference in gray matter atrophy.
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