Why the study?
Does adiponectin prevent oxidative stress-induced cardiac remodeling in cultured rat ventricular myocytes and mice?
Population
Cultured adult rat ventricular myocytes (ARVM) and wild-type (WT) and APN-deficient (APN-KO) mice
Comparison
Recombinant adiponectin pretreatment and… vs No APN pretreatment and APN-deficient mice
Design
Preclinical
Follow-up
14 days (in vivo)
Key result
Adiponectin reduced H2O2-induced cardiomyocyte hypertrophy and MMP-2 and MMP-9 activities, indicating its cardioprotective role against oxidative stress.
Authors
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Adiponectin attenuates oxidative stress effects in myocytes; hypothesis-generating for remodeling prevention, with human translation untested.
Does adiponectin prevent oxidative stress-induced cardiac remodeling in cultured rat ventricular myocytes and mice?
Adiponectin mediates cardioprotection against oxidative stress-induced remodeling via AMPK activation and inhibition of ERK and NF-κB signaling.
Essick et al. (2011) studied this question. Adiponectin reduced H2O2-induced cardiomyocyte hypertrophy and MMP-2 and MMP-9 activities, indicating its cardioprotective role against oxidative stress.