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Synapse
February 8, 20260 citations

Evaluation of the effect of trans sodium crocetinate and crocetin on reperfusion injury in acute myocardial infarction with ST-segment elevation: A double-blind, randomized, placebo-controlled clinical trial.

GEGhazaleh ElahabadiAGArash GholoobiJRJavad Ramezani

Key Points

  • To evaluate the efficacy of trans sodium crocetinate and crocetin in improving myocardial reperfusion in STEMI patients.
  • Double-blind, randomized, placebo-controlled trial
  • Administered TSC injection and crocetin tablets post-PPCI
  • Measured ST-segment resolution and cardiac remodeling outcomes
  • Improved myocardial reperfusion indicated by enhanced ST-segment resolution
  • No observed benefits in cardiac remodeling or CTIMIFC
  • Supportive safety profile for TSC and crocetin, warranting further research

Abstract

TSC (0.5 mg/kg injection pre-PPCI + 7.5 mg crocetin tablets for 3 days) administration improved myocardial reperfusion, as evidenced by enhanced ST-segment resolution, suggesting reduced reperfusion injury in STEMI patients post-PPCI. While no benefits were observed in CTIMIFC or cardiac remodeling, the safety profile and primary outcome results support further investigation. Larger trials are needed to confirm efficacy and assess long-term clinical impacts.

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Cite This Study

Elahabadi et al. (2026) studied this question.

synapsesocial.com/papers/698827670fc35cd7a8846227https://doi.org/10.22038/ajp.2025.26046
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Efficacy of Clopidrogel on Reperfusion and High-Sensitivity C-Reactive Protein in Patients with Acute Myocardial Infarction2009 · 7 citations
  2. 2Effects of intracoronary injection of nicorandil and tirofiban on myocardial perfusion and short-term prognosis in elderly patients with acute ST-segment elevation myocardial infarction after emergency PCI2020 · 29 citations
  3. 3Platelet inhibition to target reperfusion injury trial: Rationale and study design2018 · 19 citations
  4. 4The Effect of Prethrombolytic Cyclosporine‐A Injection on Clinical Outcome of Acute Anterior ST ‐Elevation Myocardial Infarction2012 · 65 citations
  5. 5Comparative Efficacy of Ticagrelor and Clopidogrel in ST-Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention: A Cardiac Magnetic Resonance Imaging-Based Pilot Study.2026