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Synapse
February 8, 20260 citations

Safety and efficacy of interventions for pain management during venipuncture in neonates: A systematic review and network meta-analysis.

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NANalina AmujiBBBharathi BalachanderTAThangaraj Abiramalatha

Key Points

  • The central aim is to evaluate the safety and efficacy of various interventions for pain management during venipuncture in neonates.
  • Systematic review of non-pharmacological and pharmacological interventions
  • Network meta-analysis comparing different analgesics
  • Assessment of pain reduction effectiveness for neonates
  • Breastfeeding was identified as the most effective intervention for pain reduction during venipuncture
  • Nonnutritive sucking (NNS) followed breastfeeding as a viable alternative
  • Both interventions are feasible in various healthcare settings

Abstract

Among various non-pharmacological and pharmacological analgesics to reduce pain during and after the venipuncture in neonate, breastfeeding (including breast milk) was the best intervention to reduce pain during venipuncture, followed by NNS. Both these are feasible interventions in all settings.

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Cite This Study

Amuji et al. (2026) studied this question.

synapsesocial.com/papers/698828210fc35cd7a88475ddhttps://doi.org/10.1177/11297298251407724
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