Photoflow Sulfur Alkylation of Sulfenamides for Direct Access of S -Methyl Sulfoximines

Key Points

• The research aims to provide a safer and faster method for synthesizing sulfilimines using photoflow techniques.
• Developed a photoflow sulfur alkylation process using diazo compounds.
• Employed a rapid reaction time of 7.5 minutes.
• Tested the method across a broad range of functional groups with 22 different molecules.
• Ensured scalability for gram-scale synthesis.
• Achieved yields between 76-95% for the synthesized sulfilimines.
• Demonstrated robustness and broad functional group tolerance.
• Facilitated late-stage drug modification efficiently.