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February 8, 2026Physical Chemistry Chemical Physics0 citationsOpen Access

Probing Histidine Tautomer by X-ray Absorption Spectroscopy for Biological and Pathological Studies

HKHyundong Hyundong KimSCSompriya ChatterjeeMKMyounwoo Kim

Key Points

  • The research aims to differentiate histidine tautomeric states to understand their impact on disease.
  • Utilized x-ray absorption spectroscopy to analyze histidine tautomer states.
  • Examined tautomer equilibrium shifts related to protein behavior.
  • Focused on implications for neurodegenerative disease mechanisms.
  • Identified critical shifts in histidine tautomer equilibrium.
  • Found associations between tautomeric states and protein misfolding.
  • Suggested potential therapeutic pathways to reduce protein aggregation.

Abstract

Differentiating histidine tautomeric states is critical for understanding their role in neurodegenerative disease pathogenesis. Shifts in tautomer equilibrium may drive protein misfolding and aggregation, suggesting potential therapeutic interventions to mitigate...

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Cite This Study

Kim et al. (2026) studied this question.

synapsesocial.com/papers/698828770fc35cd7a8847f1fhttps://doi.org/10.1039/d5cp01475a
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