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February 8, 2026The Journal of Organic Chemistry0 citations

Visible-Light Photoredox-Induced and Copper-Catalyzed Trifluoromethoxylation of Diaryliodonium Tetrafluoroborates

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JLJinjin LiMZMingxin ZhaoQHQingyun Huang

Key Points

  • To develop an efficient method for introducing trifluoromethoxy groups into aromatic systems using light and copper.
  • Utilized visible-light photoredox catalysis for aryl iodonium tetrafluoroborates
  • Employed copper as a catalyst
  • Assessed functional group compatibility and scalability
  • Successfully introduced the trifluoromethoxy group into various aromatic systems
  • Mechanistic studies indicated generation of aryl radicals through visible-light catalysis
  • Demonstrated broad functional group compatibility

Abstract

A light-induced and copper-catalyzed trifluoromethoxylation reaction of aryl iodonium tetrafluoroborates was reported. This scalable protocol demonstrates broad functional group compatibility and offers a practical and efficient strategy for the introduction of the trifluoromethoxy group into aromatic systems. Furthermore, mechanistic studies suggested that aryl radicals are generated via visible-light catalysis during the reaction.

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Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/698828850fc35cd7a88480e2https://doi.org/10.1021/acs.joc.5c03177
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