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February 8, 2026Cell & Bioscience0 citationsOpen Access

Lactylation-related gene signature as a prognostic biomarker for neuroblastoma: insights into tumor progression and immune modulation

JZJiangquan ZhuMLMuyang LuoLYLi Yuan

Key Points

  • This research aims to identify lactylation as a key factor in neuroblastoma progression and develop a gene signature for prognosis.
  • Developed a prognostic model based on a seven-gene lactylation signature.
  • Evaluated the implications of lactylation on tumor progression and therapeutic outcomes.
  • Assessed KLHL32 as a potential target for immunotherapy enhancement.
  • Established the seven-gene lactylation model for patient stratification in neuroblastoma.
  • Demonstrated that lactylation impacts tumor progression and prognosis significantly.
  • Identified KLHL32 as a promising candidate to improve immunotherapy efficacy.

Abstract

Our findings establish lactylation as a critical determinant of neuroblastoma progression and prognosis. The seven-gene lactylation-related prognostic model provides a novel tool for patient stratification and therapeutic decision-making. Additionally, KLHL32 represents a promising target for enhancing immunotherapy efficacy by modulating metabolic and immune pathways, offering new opportunities for precision treatment in high-risk neuroblastoma patients.

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Cite This Study

Zhu et al. (2026) studied this question.

synapsesocial.com/papers/698828fd0fc35cd7a8848e58https://doi.org/10.1186/s13578-026-01538-7
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