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February 8, 2026BMC Pregnancy and Childbirth0 citationsOpen Access

Meconium metabolomic profiling dysregulation and neonatal brain injury in selective fetal growth restriction

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JLJiayi LiuNHNana HuangYZYouzhen Zhang

Key Points

  • This research aims to explore the relationship between meconium metabolomic profiles and brain injury in neonates with selective fetal growth restriction (sFGR).
  • Analyzed fatty acid metabolites in meconium samples from sFGR neonates.
  • Compared metabolomic profiles between two subgroups of sFGR (sFGR-S and sFGR-L).
  • Identified potential biomarkers associated with neurological outcomes.
  • Found dysregulated fatty acid metabolites linked to severe brain injury in sFGR neonates.
  • Identified distinct metabolic profiles between sFGR-S and sFGR-L indicating different pathological mechanisms.
  • Highlighted potential for using metabolomic data as predictive biomarkers for adverse outcomes.

Abstract

Dysregulated fatty acid metabolites in the meconium of sFGR neonates are associated with severe brain injury. Divergent metabolomic profiles between sFGR-S and sFGR-L revealed distinct pathological mechanisms underlying brain injury. These findings provide novel insights into metabolic mechanisms of brain injury in sFGR and offer potential predictive biomarkers for adverse neurological outcomes.

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Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/698829520fc35cd7a8849993https://doi.org/10.1186/s12884-026-08727-9
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