The aim is to investigate the role of SATB1-AS1 in modulating inflammation in dental pulp stem cells.
Examined the effect of SATB1-AS1 on inflammatory responses in dental pulp stem cells.
Analyzed the interactions between SATB1-AS1, miR-15a-5p, and E2F3.
Assessed potential biomarkers for pulpitis using clinical samples.
SATB1-AS1 significantly suppressed inflammatory responses in dental pulp stem cells.
Identification of miR-15a-5p as a mediator of SATB1-AS1's effects.
Potential to use SATB1-AS1 as a diagnostic biomarker for pulpitis.
Abstract
This study suggests that SATB1-AS1 may serve as a novel diagnostic biomarker and therapeutic target for pulpitis, providing a potential strategy to preserve pulp vitality and improve clinical outcomes.