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February 9, 2026BMC Microbiology1 citationsOpen Access

Intestinal microbiome in very-preterm infants at one month of age and association with neurodevelopmental outcome

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CPConstance PatinCMC. MonotLOL Onestas

Key Points

  • This research aims to explore the association between gut microbiome composition and neurodevelopmental outcomes in very-preterm infants at one month of age.
  • Analyzed gut microbiome composition at one month of age
  • Identified proportions of Escherichia and Staphylococcus
  • Determined associations between microbiome and neurodevelopmental outcomes
  • Escherichia was linked to better neurodevelopmental outcomes
  • Staphylococcus proportions indicated gut immaturity
  • Escherichia production of specific metabolites supports intestinal maturation

Abstract

The gut microbiome at one month of age could be a noninvasive biomarker of gut immaturity and metabolic defects. Escherichia and Staphylococcus proportions were found to be the best indicators of physiological maturity and immaturity, respectively. Escherichia may help the process of intestinal maturation in preterm infants through specific metabolites production and is associated with a better neurodevelopment.

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Cite This Study

Patin et al. (2026) studied this question.

synapsesocial.com/papers/69897996f0ec2af6756e754dhttps://doi.org/10.1186/s12866-026-04789-z
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