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February 9, 2026BMC Microbiology0 citationsOpen Access

Elucidating the functions of fabF1 and fabF2 in Pseudomonas aeruginosa: implications for fatty acid metabolism and pathogenicity

ZHZhe HuJYJunfei YuMLMengchen Li

Key Points

  • The aim is to explore how fabF1 and fabF2 contribute to fatty acid metabolism and virulence in Pseudomonas aeruginosa.
  • Characterization of fabF1 and fabF2 genes
  • Assessment of fatty acid biosynthesis roles
  • Evaluation of virulence factor production
  • Analysis of motility in Pseudomonas aeruginosa
  • FabF1 and FabF2 are essential for fatty acid biosynthesis.
  • Alterations in fabF1 and fabF2 affect virulence factor production significantly.
  • Motility is impaired when either fabF gene is disrupted.

Abstract

These findings highlight the critical roles of fabF1 and fabF2 in fatty acid biosynthesis, virulence factor production, and motility in P. aeruginosa. This study provides new insights into the functional divergence of FabF homologs and identifies potential targets for antimicrobial development.

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Cite This Study

Hu et al. (2026) studied this question.

synapsesocial.com/papers/69897a35f0ec2af6756e89bdhttps://doi.org/10.1186/s12866-026-04824-z
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