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February 11, 2026The Aging Male0 citationsOpen Access

Association between allostatic load and long-term survival in populations with high or low PSA levels: a national population-based analysis from NHANES 2003–2010

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YLyu liuXTXingzhao TianKZKun Zhu

Key Result

Higher allostatic load index (ALI) was significantly associated with increased PSA levels, all-cause mortality, and cardiovascular disease risk, but not with cancer-specific mortality.

Key Points

  • The aim is to explore the relationship between allostatic load and survival rates in populations with varying PSA levels.
  • Utilized national health data from NHANES 2003–2010
  • Analyzed the impact of allostatic load index (ALI) on PSA levels and mortality
  • Examined associations with cardiovascular disease risk and specific cancer mortality
  • Higher allostatic load index was positively linked to increased PSA levels
  • Significant association found with all-cause mortality
  • No statistically significant link established for cancer-specific mortality risk

Structured PICO

Is higher allostatic load associated with increased all-cause mortality and cardiovascular disease risk in populations with high or low PSA levels?

P
Population
Populations with high or low PSA levels from NHANES 2003–2010
I
Intervention
Higher Allostatic Load Index (ALI)
C
Comparator
Lower Allostatic Load Index (ALI)
O
Outcome
All-cause mortality and cardiovascular disease riskhard clinical

Higher allostatic load is associated with increased all-cause mortality and cardiovascular disease risk in populations stratified by PSA levels.

Abstract

In a specific range, higher ALI was significantly and positively associated with PSA levels, all-cause mortality, and cardiovascular disease risk, though its link to cancer-specific mortality risk was not statistically significant in this study.

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Cite This Study

liu et al. (2026) studied this question. Higher allostatic load index (ALI) was significantly associated with increased PSA levels, all-cause mortality, and cardiovascular disease risk, but not with cancer-specific mortality.

synapsesocial.com/papers/698c1c65267fb587c655edc8https://doi.org/10.1080/13685538.2026.2625508
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