ABSTRACT Immune dysregulation is involved in Parkinson's disease (PD), but the roles of C‐X‐C motif chemokine receptor 3 (CXCR3)/chemokine receptor 6 (CXCR6) on T cells and their correlation with peripheral inflammation remain unclear. This study investigated their expression on peripheral blood T cells and correlation with inflammation in PD. A total of 36 PD patients and 26 healthy controls were enrolled; their clinical information and laboratory test results (including the systemic immunoinflammatory index SII, neutrophil‐to‐lymphocyte ratio NLR, monocyte‐to‐lymphocyte ratio MLR, platelet‐to‐lymphocyte ratio PLR, monocyte‐to‐high‐density lipoprotein ratio MHR, and erythrocyte distribution width over platelets ratio RPR) were recorded. Meanwhile, a multicolour flow cytometry protocol using six cell surface antibodies (CD3, CD4, CD8, CD45RO, CXCR3, and CXCR6) was applied. The results showed that CD8 + T cells were significantly reduced in the PD group compared with healthy controls ( p 0.05). Compared with healthy controls, PD patients had significantly increased peripheral blood C‐reactive protein (CRP) levels ( p < 0.001) but remarkably decreased monocytes, lymphocytes, and MHR ( p < 0.01). Collectively, the upregulated expression of CXCR3 and CXCR6 predominantly on CD8 + T lymphocytes may contribute to PD pathogenesis, though no significant correlation between the expression of these receptors and peripheral inflammation was observed.
Zhang et al. (2026) studied this question.