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February 12, 2026Journal of Infection2 citationsOpen Access

Neisseria meningitidis serogroup W ST-4821 clonal complex shares a highly conserved capsular switching pattern with ST-11 clonal complex strains

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JHJiebin HuangYJYue JiangPLPanpan Lv

Key Points

  • This research aims to explore the capsular switching patterns in Neisseria meningitidis ST-4821 and ST-11 strains.
  • Examined capsular switching events in cc4821 isolates.
  • Identified potential donor strains involved in the switching process.
  • Analyzed the fitness costs associated with capsular switching.
  • C→W capsular switching was observed in cc4821 isolates.
  • A conserved switching pattern among MenW strains was confirmed.
  • A fitness cost was associated with the capsular switching process.

Abstract

C→W capsular switching with a cc22 strain as the potential donor was identified in cc4821 isolates, which is a highly conserved pattern among MenW strains. A fitness cost was found in the capsular switching.

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Cite This Study

Huang et al. (2026) studied this question.

synapsesocial.com/papers/698d6d445be6419ac0d52250https://doi.org/10.1016/j.jinf.2026.106698
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hyperinvasive and quinolone-resistant meningococci cc4821 achieved immune evasion through capsule switching2026
  2. 2Genomic and evolutionary insights into a novel Neisseria meningitidis genogroup W clonal complex 11 variant with dual resistance to penicillin and azithromycin in Spain2026
  3. 3Pathogenicity variation of CC4821 Neisseria meningitidis in China from 2005 to 20242026
  4. 4Microevolution associated with clonal expansion of a hypervirulent, penicillin-resistant lineage of Neisseria meningitidis in Western Australia2025
  5. 5Atypical clinical manifestations of a fatal case of generalized meningococcal infection caused by Neisseria meningitidis serogroup W, part of the clonal complex cc112025