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February 12, 2026Organic & Biomolecular Chemistry0 citations

B(C₆F₅)₃/I₂ Co-Mediated Cascade 4 + 2/3 + 2 Cyclization to Spiroimidazolines

HQHuanyi QiuJFJingxi FangMGMingyan Guan

Key Points

  • The research aims to develop an efficient method for synthesizing spiroimidazolines through cascade cyclization.
  • Utilized B(C₆F₅)₃ as a catalyst in 1 mol% concentration.
  • Employed a cascade [4 + 2]/[3 + 2] cyclization approach.
  • Focused on achieving high step- and atom-economy in the synthesis.
  • Successfully synthesized structurally novel spiroimidazolines.
  • Demonstrated high efficiency in the cyclization process with minimal waste.
  • Achieved significant improvements in the synthesis route compared to traditional methods.

Abstract

A highly step- and atom-economical cascade 4 + 2/3 + 2 cyclization has been developed for the synthesis of structurally novel spiroimidazolines. Catalyzed by only 1 mol% B(C₆F₅)₃ in the...

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Cite This Study

Qiu et al. (2025) studied this question.

synapsesocial.com/papers/698d6e055be6419ac0d535c2https://doi.org/10.1039/d5ob01941a
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