PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
February 12, 2026Investigative Ophthalmology & Visual Science1 citationsOpen Access

Microvascular Volume Loss Exceeds Nerve Fiber Layer but Not Neuroretinal Rim Tissue Loss During Progression of Nonhuman Primate Experimental Glaucoma

View Full Paper
MDMichaela DunnGCGrant CullJRJuan Reynaud

Key Points

  • This research aims to investigate the progression of microvascular volume loss compared to nerve fiber layer and neuroretinal rim tissue loss in glaucoma.
  • Evaluated nonhuman primate models of experimental glaucoma
  • Assessed microvasculature within the RNFL
  • Monitored progression of both microvascular and tissue loss
  • Microvascular volume loss occurs early in glaucoma progression
  • Loss of microvasculature exceeds the loss of nerve fiber layer
  • Neuroretinal rim tissue loss does not match microvascular loss rate

Abstract

Progressive loss of functional microvasculature (adequately perfused capillaries) within the RNFL, occurring early and in excess of the neuroglial tissue it supplies, supports future investigation of therapeutic strategies that target vascular function.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Dunn et al. (2026) studied this question.

synapsesocial.com/papers/698d6ebb5be6419ac0d54700https://doi.org/10.1167/iovs.67.2.24
Ask AI
Helpful
Bookmark
Share
View Full Paper

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Quantification of diabetic macular ischemia using novel three‐dimensional optical coherence tomography angiography metrics2020 · 34 citations
  2. 2Systemic Arterial Stiffness and Choroidal Microvascular Insufficiency on the Structural Progression of Normal Tension Glaucoma2024 · 6 citations
  3. 3Normal Corneal Thickness and Endothelial Cell Density in Rhesus Macaques ( Macaca mulatta )2022 · 7 citations
  4. 4Detailed Vascular Anatomy of the Human Retina by Projection-Resolved Optical Coherence Tomography Angiography2017 · 859 citations
  5. 5Reduction of Optic Disc Microvasculature and Retinal Nerve Fiber Layer Thinning in Patients With Glaucoma2024 · 9 citations