Periprocedural myocardial infarction defined by SCAI was associated with a 29.4% rate of death/myocardial infarction at 2 years, compared to 10.7% without PMI (P=0.015).
Does the SCAI definition of periprocedural myocardial infarction better predict late death or MI compared to the 2007 and 2012 universal definitions in patients undergoing PCI?
The SCAI definition of periprocedural myocardial infarction, which requires higher biomarker thresholds, is more strongly associated with late death and MI compared to the 2007 and 2012 universal definitions.
Background Periprocedural myocardial infarction ( PMI ) has had several definitions in the last decade, including the Society for Cardiovascular Angiography and Interventions ( SCAI ) definition, that requires marked biomarker elevations congruent with surgical PMI criteria. Methods and Results The aim of this study was to examine the definition‐based frequencies of PMI and whether they influenced the reported association between PMI and increased rates of late death/ myocardial infarction ( MI ). We studied 742 patients; 492 (66%) had normal troponin T (TnT) levels and 250 (34%) had elevated, but stable or falling, TnT levels. PMI , using the 2007 and the 2012 universal definition, occurred in 172 (23.2%) and in 99 (13.3%) patients, respectively, whereas 19 (2.6%) met the SCAI PMI definition ( P <0.0001). Among patients with PMI using the 2012 definition, occlusion of a side branch ≤1 mm occurred in 48 patients (48.5%) and was the most common angiographic finding for PMI . The rates of death/ MI at 2 years in patients with, compared to those without, PMI was 14.7% versus 10.1% ( P =0.087) based on the 2007 definition, 16.9% versus 10.3% ( P =0.059) based on the 2012 definition, and 29.4% versus 10.7% ( P =0.015) based on the SCAI definition. Conclusion In this study, PMI , according to the SCAI definition, was associated with more‐frequent late death/ MI , with ≈20% of all patients, who had PMI using the 2007 universal MI definition, not having SCAI ‐defined PMI . Categorizing these latter patients as SCAI ‐defined no PMI did not alter the rate of death/ MI among no‐ PMI patients.
Idris et al. (2014) studied this question. Periprocedural myocardial infarction defined by SCAI was associated with a 29.4% rate of death/myocardial infarction at 2 years, compared to 10.7% without PMI (P=0.015).