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February 13, 20260 citationsOpen Access

Assessment of PBC Pruritus From the ITCH-E Study: Quality of Life, Productivity, and Treatment Experiences

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CLCynthia LevyZYZobair YounossiMMMarlyn J. Mayo

Key Points

  • To evaluate how pruritus affects quality of life and treatment experiences in patients with primary biliary cholangitis.
  • Patients with PBC were recruited from a physician panel and advocacy group.
  • Participants were grouped based on pruritus severity using a numerical rating scale.
  • Multiple questionnaires were utilized to measure health-related quality of life and treatment experiences, including EQ-5D and the PBC-40.
  • Analysis included regression models to control for confounding factors.
  • The moderate/severe pruritus group reported significantly worse health-related quality of life scores compared to the no/mild group.
  • Activity impairment was greater in the MSP group (57%) than in the NMP group (36%).
  • The employment rate was lower in the MSP group (42%) compared to the NMP group (53%).
  • Less than 25% of participants in the MSP group were receiving treatment for pruritus.

Abstract

Background p < 0.001). The MSP group had a lower employment rate (42%) than the NMP group (53%). Fewer than 25% of the MSP group were receiving itch treatment. Conclusions: Individuals with PBC and pruritus report limited pruritus treatment use and minimal itch relief. Those with moderate/severe pruritus experience a greater HRQoL burden and reduced activity compared to those with mild/no pruritus. This highlights the need for effective treatments that ameliorate pruritus in patients with PBC.

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Cite This Study

Levy et al. (2025) studied this question.

synapsesocial.com/papers/698ebf3485a1ff6a930166c1https://doi.org/10.5167/uzh-291349
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