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February 14, 2026Brain SciencesOpen Access

Malonyl-CoA Decarboxylase: A Spotlight on Brain Aspects

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Authors

MFMonique Fonseca-TeixeiraEBElaine Silva BritoCBClara Beltrao-Valente

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Overview

Investigates malonyl-CoA decarboxylase's influence on brain health, suggesting new treatment avenues for metabolic disorders.

Key Points

  • Examine the role and regulation of malonyl-CoA decarboxylase in brain physiology and pathology.
  • Discussed enzyme expression and regulatory pathways in the central nervous system.
  • Reviewed implications of MCD deficiency and its effects on brain health.
  • Highlighted pharmacological modulation studies in metabolic contexts.
  • Malonyl-CoA decarboxylase is crucial in regulating fatty acid levels in the brain.
  • Inherited MCD deficiency leads to toxic malonic acid accumulation and brain damage.
  • Pharmacological interventions targeting MCD show potential in treating metabolic disorders.

Cite This Study

Fonseca-Teixeira et al. (2026) studied this question.

synapsesocial.com/papers/699011032ccff479cfe57706https://doi.org/10.3390/brainsci16020220
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