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February 14, 2026Chemical Communications0 citationsOpen Access

Base-catalyzed switchable reactivity of N-acyl-α-aminonitriles: oxidative decyanation to imides and hydrolysis to amides in batch and flow

VMVikraman Ganesh MoorthiVSVijay Thavasianandam SeenivasanSNSharmila Nokku

Key Points

  • The aim is to explore the reactivity of N-acyl-α-aminonitriles to synthesize imides and amides using base catalysis.
  • Utilized a base-catalyzed approach without transition metals.
  • Implemented both batch and continuous-flow reaction conditions.
  • Varied oxygen exposure to assess selectivity for imides versus amides.
  • Successfully synthesized imides in the presence of air or O₂.
  • Achieved hydrolysis to form amides under controlled conditions.
  • Showed versatility of the method in different setups with consistent results.

Abstract

A base-catalyzed, transition-metal-free synthesis of imides and amides from N-acyl-α-aminonitriles is reported under batch and continuous-flow conditions. Imides are selectively formed in the presence of open air or an O₂...

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Cite This Study

Moorthi et al. (2026) studied this question.

synapsesocial.com/papers/699011172ccff479cfe5789bhttps://doi.org/10.1039/d5cc05918f
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