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February 14, 2026American Journal of Respiratory Cell and Molecular Biology

RUNX1 is a mediator of fibrotic activation and epigenetic memory in lung fibroblasts

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Authors

RGRachel M. GilbertDJDakota L. JonesJWJack Wellmerling

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Overview

Findings reveal RUNX1 drives fibrotic activation and memory in lung fibroblasts, indicating therapeutic targets for fibrosis.

Key Points

  • The central aim is to investigate the role of RUNX1 in fibrotic activation and the epigenetic memory of lung mesenchymal cells following injury.
  • Used genetic lineage labeling to mark lung mesenchyme prior to injury.
  • Conducted multi-modal analyses on isolated lung mesenchyme during fibrotic response.
  • Compared fresh isolated lung mesenchyme to cultured samples.
  • Performed targeted knockdown of RUNX1 to assess its role in fibrotic activation.
  • RUNX1 is identified as a crucial driver of fibrotic activation and memory.
  • Lung mesenchyme shows enhanced fibrotic program upon re-injury.
  • Knockdown of RUNX1 reduces fibrotic mesenchymal activation immediately after isolation.
  • Effectiveness of RUNX1 knockdown decreases with culture duration, indicating its importance in early activation and long-term memory.

Cite This Study

Gilbert et al. (2026) studied this question.

synapsesocial.com/papers/699011172ccff479cfe578dchttps://doi.org/10.1093/ajrcmb/aanag022
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