Asymmetric Synthesis of Planar-chiral Metacyclophanes via Aromatic Amination enabled Enantioselective Desymmetrization

Key Points

• The research aims to explore asymmetric synthesis methods for planar-chiral metacyclophanes through enantioselective desymmetrization.
• Utilized aromatic amination techniques for synthesis
• Focused on desymmetrization processes
• Analyzed the chirality of synthesized compounds
• Successfully synthesized planar-chiral metacyclophanes
• Achieved high levels of enantioselectivity
• Demonstrated novel pathways for macrocyclic compound synthesis