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February 14, 2026JACC Case Reports0 citationsOpen Access

Achilles Tendon Xanthoma Inflammation Revealed by FDG-PET/CT in Familial Hypercholesterolemia

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TNTakaharu NakayoshiNTNobuhiro TaharaYSYayoi Sakata

Key Points

  • To assess the inflammation of xanthomas using FDG-PET/CT in familial hypercholesterolemia patients.
  • Utilized FDG-PET/CT imaging to evaluate metabolic activity of xanthomas.
  • Analyzed the impact of short-term and prolonged lipid-lowering treatments on inflammation.
  • Assessed phenotypic differences related to disease stage and lipid exposure.
  • Xanthomas showed ongoing metabolic activity despite short-term lipid-lowering therapy.
  • Prolonged lipid-lowering treatment appeared to reduce inflammation levels in xanthomas.
  • The findings highlight the influence of cumulative lipid exposure on disease progression.

Abstract

These findings show that xanthomas exhibit persistent metabolic activity despite short-term lipid lowering, whereas prolonged therapy may attenuate inflammation. Phenotypic differences underscore roles of disease stage, cumulative lipid exposure, and treatment duration. FDG-PET/CT provides metabolic information for risk assessment and therapeutic monitoring.

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Cite This Study

Nakayoshi et al. (2026) studied this question.

synapsesocial.com/papers/699011712ccff479cfe581a0https://doi.org/10.1016/j.jaccas.2026.106949
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Bilateral Achilles Tendon Xanthomas in a 17-Year-Old Female: A Clinicoradiological Case Report2026 · 2 citations
  2. 2Familial Hypercholesterolemia with Bilateral Recurrent Extensor Tendon Xanthomas: A Case Report2025
  3. 3Cutaneous Xanthomas in a Young Boy – Markers of Homozygous Familial Hypercholesterolemia2025
  4. 4A Multisystemic Presentation of Familial Hypercholesterolaemia: A Case Report2025
  5. 5Intertriginous Xanthomas: Clues to Homozygous Familial Hypercholesterolemia2024