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February 14, 2026Biomaterials Science0 citations

Acidic pH-triggered AIE nanoparticles covalently cross-linking for enhanced tumor imaging and photodynamic therapy

WZWeiqi ZaiHJHuiling JiJLJincheng Li

Key Points

  • The research aims to develop pH-responsive nanoparticles for enhanced tumor imaging and therapeutic efficacy.
  • Synthesis of acidic pH-responsive polymers, PCL-PAE-DBCO and PCL-PAE-N3.
  • Evaluation of nanoparticle accumulation and retention at tumor sites.
  • Assessment of tumor imaging efficacy and photodynamic therapy outcomes.
  • Nanoparticles showed significant accumulation at tumor sites compared to non-responsive counterparts.
  • Enhanced imaging clarity and tumor response to photodynamic therapy were observed.
  • Covalent cross-linking improved stability and therapeutic effectiveness of the nanoparticles.

Abstract

The therapeutic effect of tumors heavily relies on the accumulation and retention of nanomaterials at the tumor site. In here, we developed two acidic pH-responsive protonated PCL-PAE-DBCO and PCL-PAE-N3 polymers,...

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Cite This Study

Zai et al. (2026) studied this question.

synapsesocial.com/papers/699011812ccff479cfe58322https://doi.org/10.1039/d5bm01655j
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