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February 14, 2026Organic & Biomolecular Chemistry0 citations

The Ugi-Joullié three-component (UJ-3CR) and related reactions. Recent developments, mechanistic aspects and synthesis of natural products and bioactive compounds

NDNatalia A. Lenarduzzi D'emilioPAPaula K Paz ArmeroASArturo R. Mendoza Salgado

Key Points

  • This research aims to explore recent advancements and mechanistic insights into the Ugi-Joullié three-component reaction.
  • Detailed examination of the Ugi-Joullié reaction mechanism.
  • Synthesis of polysubstituted nitrogen heterocycles from specified substrates.
  • Analysis of recent developments in methodologies for natural product synthesis.
  • Efficient formation of nitrogen heterocycles documented.
  • Novel methodologies for synthesizing bioactive compounds highlighted.
  • Progress in mechanistic understanding of the reaction pathways established.

Abstract

The Ugi-Joullié three-component reaction evolved from the classic Ugi four-component reaction and enables the facile and efficient formation of polysubstituted nitrogen heterocycles from cyclic imines, isonitriles and carboxylic acids. Recent...

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Cite This Study

D'emilio et al. (2025) studied this question.

synapsesocial.com/papers/699011812ccff479cfe58424https://doi.org/10.1039/d5ob02009c
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