High-cholesterol diet fuels myeloma progression, dysregulates adipokine expression in vivo, and impairs treatment response ex vivo

Key Points

• To investigate how a high-cholesterol diet affects myeloma progression and treatment response.
• Administered high-cholesterol diet in myeloma models in vivo.
• Evaluated adipokine expression levels.
• Assessed treatment responses ex vivo.
• High-cholesterol diet accelerated myeloma progression.
• Adipokine expression was significantly altered.
• Treatment responses were negatively impacted by diet.