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February 14, 2026Annals of Laboratory Medicine0 citationsOpen Access

Monthly Biological Variation of Five Lung Cancer Markers in Healthy Older Individuals: Evidence from Combined Prospective Cohort and Real-World Data Analyses

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ZHZiyang HanDYDan YangHWHongyi Wang

Key Points

  • The research aims to establish a comprehensive database of biological variation for lung cancer biomarkers in elderly Asians.
  • Combined prospective cohort and real-world data analyses
  • Monthly monitoring of five lung cancer biomarkers
  • Focus on healthy older individuals
  • Stable monthly variation of biomarkers was identified
  • Personalized reference control values (RCVs) could enhance clinical interpretation
  • Findings enable earlier therapeutic interventions for aging individuals

Abstract

This study establishes the first comprehensive BV database for lung cancer biomarkers in elderly Asians. Stable monthly variation enables flexible monitoring protocols. Our findings support implementing personalized RCVs for clinical interpretation and facilitate earlier therapeutic interventions for aging individuals.

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Cite This Study

Han et al. (2026) studied this question.

synapsesocial.com/papers/699012032ccff479cfe58b99https://doi.org/10.3343/alm.2025.0528
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