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February 16, 2026Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration1 citationsOpen Access

Systemic immune-metabolic interactions in patients with amyotrophic lateral sclerosis: correlations of plasma cytokines with metabolic status

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SHStephanie L. HoweCHCory J. HoldomPMPamela A. McCombe

Key Points

  • To investigate systemic immune-metabolic interactions and their relationship with plasma cytokines in ALS patients.
  • Correlation analysis of plasma cytokines with metabolic status in ALS patients.
  • Assessment of levels of IL-6 and MCP-1 in plasma samples.
  • Longitudinal and tissue-specific analyses suggested for future studies.
  • Modest elevations in plasma levels of IL-6 and MCP-1 were confirmed in ALS patients.
  • No significant correlation was found between circulating cytokines and hypermetabolism.
  • Need for further studies to clarify immune-metabolic mechanisms contributing to disease heterogeneity in ALS.

Abstract

Findings confirm modest elevations in plasma levels of IL-6 and MCP-1 in ALS but provide no evidence that circulating cytokines correlate with hypermetabolism. Further studies integrating longitudinal and tissue-specific analyses are needed to clarify immune-metabolic mechanisms contributing to disease heterogeneity in ALS.

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Cite This Study

Howe et al. (2026) studied this question.

synapsesocial.com/papers/69926503eb1f82dc367a0e8bhttps://doi.org/10.1080/21678421.2026.2627902
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