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February 16, 2026Organic Letters0 citations

Modular Access to Boron Tripyrrolic Complexes from a Sequential Buchwald–Hartwig Amination/Boron Complexation Reaction

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LZLiang ZhangZLZhongxin LiGLGuojun Li

Key Points

  • To develop a modular synthesis for boron tripyrrolic complexes with specific optical properties.
  • Utilized sequential Buchwald-Hartwig amination and boron complexation reactions.
  • Started with readily accessible α,α-dibromodipyrromethenes.
  • Synthesized analogs with functionalization at B-, meso-, and α-positions.
  • Resulted in novel boron tripyrrolic analogs, specifically BOTPY.
  • Achieved tunable absorption and fluorescence with ΦF up to 0.36.
  • Demonstrated applicability for lipid droplet imaging.

Abstract

We report a modular synthesis of novel boron tripyrrolic analogs, BOTPY, via a sequential Buchwald-Hartwig amination/boron complexation reaction from readily accessible α,α-dibromodipyrromethenes. This approach provides facile access to structurally enriched B-, meso-, and α-positional functionalized fluorophores, possessing tunable absorption and fluorescence (ΦF up to 0.36) in the visible to NIR region as well as applicability for lipid droplet imaging.

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Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69926503eb1f82dc367a0e8fhttps://doi.org/10.1021/acs.orglett.6c00052
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