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This research aims to uncover how USP7 and RNF40 maintain KDM6A stability and influence susceptibility to coronaviruses.

February 17, 2026Advanced ScienceOpen Access

Antagonistic Ubiquitin Switching by USP7 and RNF40 Orchestrates KDM6A Homeostasis to License Coronavirus Susceptibility

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Research reveals that USP7 and RNF40 regulate KDM6A, impacting coronavirus infection, suggesting potential therapies.

This research aims to uncover how USP7 and RNF40 maintain KDM6A stability and influence susceptibility to coronaviruses.
Inhibition of USP7 was performed using genetic and pharmacological approaches.
Assessment of coronavirus receptor expression levels following USP7 inhibition.
Analysis of KDM6A stability through ubiquitin linking and degradation pathways.
Evaluation of the impact of USP7 inhibitors in human airway and intestinal epithelial cells and in mice.
USP7 enhances the expression of coronavirus receptors ACE2, DPP4, and Ceacam1, promoting viral entry.
Inhibition of USP7 leads to decreased KDM6A stability and subsequent reduction in viral receptor expression.
FT671 and XL177A reduced susceptibility to various coronaviruses, including major variants of concern.
Mice treated with FT671 exhibited reduced Ceacam1 expression and increased resistance to MHV-A59 infection.

Huang et al. (2026) studied this question.

View Full Paper

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February 17, 2026Advanced ScienceOpen Access

View Full Paper

Ask AI

Bookmark

Authors

Research reveals that USP7 and RNF40 regulate KDM6A, impacting coronavirus infection, suggesting potential therapies.

This research aims to uncover how USP7 and RNF40 maintain KDM6A stability and influence susceptibility to coronaviruses.
Inhibition of USP7 was performed using genetic and pharmacological approaches.
Assessment of coronavirus receptor expression levels following USP7 inhibition.
Analysis of KDM6A stability through ubiquitin linking and degradation pathways.
Evaluation of the impact of USP7 inhibitors in human airway and intestinal epithelial cells and in mice.
USP7 enhances the expression of coronavirus receptors ACE2, DPP4, and Ceacam1, promoting viral entry.
Inhibition of USP7 leads to decreased KDM6A stability and subsequent reduction in viral receptor expression.
FT671 and XL177A reduced susceptibility to various coronaviruses, including major variants of concern.
Mice treated with FT671 exhibited reduced Ceacam1 expression and increased resistance to MHV-A59 infection.

Huang et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark