Purpose: To report a rare case of secondary multiple evanescent white dot syndrome (MEWDS) associated with active acute central serous chorioretinopathy (CSCR). Methods: Medical records and multimodal retinal imaging (MMI) were retrospectively evaluated. MMI included ultra-widefield color fundus photography, fundus autofluorescence, and spectral-domain optical coherence tomography. Results: A 35-year-old male presented with new-onset vision decrease in one eye and acute bilateral CSCR. The patient endorsed a high stress job and recent steroid injection therapy. MEWDS developed shortly thereafter, but both the CSCR leak and the MEWDS lesions resolved after two months of observation. Conclusion: Secondary MEWDS can be triggered by various concomitant retinal diseases possibly due to an autoimmune phenomenon, and it is possible that pachychoroid disease and acute CSCR may represent additional triggering disorders in that spectrum.
Hsu et al. (2026) studied this question.