PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
February 19, 2026Journal of Comparative Effectiveness Research2 citationsOpen Access

Real-world clinical outcomes of patients with localized prostate cancer treated with radical prostatectomy in SEER-Medicare

View Full Paper
LKLawrence I. KarshSDShawn DuJHJ. J. He

Key Points

  • This study aims to analyze clinical outcomes of patients with low and high-risk localized prostate cancer following radical prostatectomy.
  • Conducted a retrospective analysis using the SEER-Medicare database.
  • Included patients aged ≥65 diagnosed with localized prostate cancer from 2012 to 2019.
  • Stratified eligible patients into low/intermediate-risk and high-risk cohorts.
  • Utilized Kaplan–Meier method and Cox proportional-hazards model for survival analysis.
  • HR-LPC patients experienced significantly shorter overall and metastatic free survival compared to LIR-LPC.
  • HR-LPC was associated with approximately 70% increased risk of all-cause death compared to LIR-LPC.
  • HR-LPC had a 2.5-fold increased risk for metastasis or death and ninefold increased risk for advanced treatment initiation compared to LIR-LPC.

Abstract

Aim: This study examined the clinical outcomes of patients in the US with low/intermediate-risk localized prostate cancer (LIR-LPC) and high-risk localized prostate cancer (HR-LPC) who received radical prostatectomy (RP) as initial treatment. Materials confidence interval CI:1.39–2.12), 2.5-fold increased risk for metastasis or death (HR: 2.57; CI: 2.14–3.09), and ninefold increased risk for initiating advanced treatments (HR: 9.06; CI: 6.22–13.18) compared with patients with LIR-LPC. Conclusion: In patients with LPC who received RP as initial definitive treatment, high risk is strongly associated with suboptimal clinical outcomes. Novel therapeutic approaches are needed to enhance the management and improve the outcomes for this patient population.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Karsh et al. (2026) studied this question.

synapsesocial.com/papers/6996a7a5ecb39a600b3ed92ehttps://doi.org/10.57264/cer-2025-0004
Ask AI
Helpful
Bookmark
Share
View Full Paper