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Synapse
February 19, 20260 citationsOpen Access

Childhood Trauma and Epigenetic Markers: Revealing Leads to Adult Mental Health

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ALAbigail-Lois Naa Adoley Lomotey

Key Points

  • This study aims to examine the relationship between childhood trauma and its effects on adult mental health via epigenetic markers.
  • Adopted a qualitative research approach
  • Used interpretive phenomenological design to understand lived experiences
  • Conducted in-depth, semi-structured interviews with adults aged 25 and above
  • Analysed data using thematic analysis to identify patterns across narratives
  • Childhood trauma leads to long-lasting emotional and psychological consequences
  • Participants experienced altered stress responses and emotional dysregulation
  • Increased vulnerability to mental health challenges in adulthood was reported
  • Participants expressed intuitive awareness of biological effects of early trauma

Abstract

Abstract The study explored the relationship between childhood trauma and epigenetic markers and how these processes were perceived to influence adult mental health outcomes. Childhood trauma has been widely associated with long-term psychological disorders; however, there remains limited qualitative understanding of how early adverse experiences are internalised and interpreted as having lasting biological and psychological effects. The study adopted a qualitative research approach, using an interpretive phenomenological design to capture the lived experiences of adults with a history of childhood trauma. Data were collected through in-depth, semi-structured interviews with adults aged 25 years and above who reported exposure to adverse childhood experiences. Thematic analysis was employed to analyse the data and identify recurring patterns of meaning across participants’ narratives. The findings revealed that childhood trauma was experienced as having enduring emotional and psychological consequences, including altered stress responses, emotional dysregulation, and increased vulnerability to mental health challenges in adulthood. Participants also described perceived bodily and internal changes, suggesting an intuitive awareness of the biological embedding of early trauma. The study further found that meaning-making and increased awareness of trauma’s long-term effects played a role in coping and psychological adjustment. The study concluded that childhood trauma may become embedded within psychological and biological systems, shaping adult mental health outcomes. The findings highlight the importance of trauma-informed mental health interventions that integrate psychological and biological perspectives.

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Cite This Study

Abigail-Lois Naa Adoley Lomotey (2026) studied this question.

synapsesocial.com/papers/6996a7ffecb39a600b3ee491https://doi.org/10.5281/zenodo.18662387
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of Early Childhood Trauma on Adult Mental Health2024 · 2 citations
  2. 2The Long Shadow of Childhood Adversity: A Systematic Review of Adult Psychiatric Disorders Linked to Abuse, Neglect, and Trauma2026
  3. 3Epigenetic changes associated with multi-generational trauma: characterization, mechanisms, and therapeutics2026
  4. 4Exploring the Effects of Childhood Trauma on Mental Health Outcomes among Young Adults: An Empirical Study2025
  5. 5Childhood trauma is linked to epigenetic age deceleration in young adults with previous youth residential care placements2024 · 11 citations