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February 19, 2026Connective Tissue Research0 citations

Collagen I alleviates UVB-induced oxidative DNA damage and inhibits YAP-p73 apoptotic pathway in human keratinocytes HaCaT

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YZYuying ZhuFGFei GuoGuangzhou Women and Children Medical CenterTJTianyu Ji

Key Points

  • The aim is to evaluate how collagen I affects UVB-induced oxidative DNA damage and apoptosis in keratinocytes.
  • Used human keratinocyte cell line HaCaT
  • Applied UVB irradiation to induce oxidative stress
  • Assessed ROS production and apoptosis
  • Evaluated the role of mitophagy in protecting cells
  • Collagen I significantly reduced ROS production in UVB-irradiated cells
  • Decreased apoptosis via inhibition of the YAP-p73 pathway
  • Restored mitophagy contributed to DNA damage alleviation

Abstract

Collagen I-coating protects UVB-irradiated cells from YAP-p73 mediated apoptosis through restricting ROS production and thus alleviating DNA damages, owing to the restored mitophagy. Our study supports the clinical application of collagen products as anti-UVB agents.

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Cite This Study

Zhu et al. (2026) studied this question.

synapsesocial.com/papers/6996a84cecb39a600b3eed48https://doi.org/10.1080/03008207.2026.2630869
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