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February 19, 2026Clinical Cancer Research0 citations

Digital Patient-Derived Organoid Guiding Therapy Post Antibody Drug Conjugates in Metastatic...

Abstract PS1-09-29: A Rapid Digital Patient-Derived Organoid Guiding Therapy After Antibody Drug Conjugates (ADC)s In Patients with Metastatic Breast CancerYY1 YY1The size limit (including title and body) is 3,400 characters; this does not include spaces

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Authors

YYY. YuanJBJin Sun BitarDLD. Lin

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Overview

Prospective clinical study assesses drug response in metastatic breast cancer using digital organoids, suggesting personalized treatment strategies.

Key Points

  • This study aims to evaluate the effectiveness of a digital patient-derived organoid platform to predict treatment responses in patients with metastatic breast cancer after antibody drug conjugate therapy.
  • Established an IRB for collecting fresh tumor biopsies from metastatic breast cancer patients treated with ADCs.
  • Generated digital patient-derived organoids from fresh tumor samples for assessing drug sensitivity.
  • Conducted dosing experiments with various ADCs and chemotherapy agents to evaluate organoid responses.
  • 28 tumor tissues were processed, yielding a 57.9% success rate in establishing viable organoids.
  • Prior exposure to ADCs correlated with reduced sensitivity of organoids to the same agents, indicating acquired resistance.
  • DPOs from heavily pretreated patients remained responsive to alternative therapies, suggesting new treatment opportunities.

Cite This Study

Yuan et al. (2026) studied this question.

synapsesocial.com/papers/6996a84cecb39a600b3eeeb9https://doi.org/10.1158/1557-3265.sabcs25-ps1-09-29
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