A Comparative Clinical Study to Evaluate the Efficacy of Thumbi Taila and Amritadya Taila Marsha Nasya Followed by Pratimarsha Nasya in the Management of Hypothyroidism

Background and Objective: Hypothyroidism is a hypometabolic disorder due to deficient thyroid hormone production and is among the most common endocrine diseases worldwide. Ayurveda correlates it with Kapha–Vata dosha imbalance, Jatharagni dushti, and Dhatwagnimandya leading to metabolic slowdown and symptoms like weight gain, fatigue, constipation, and hair fall. As the thyroid lies in the Urdhva Jatrugata region, Nasya Karma is considered a prime therapy. This study evaluated and compared the efficacy of Thumbi Taila and Amritadya Taila Nasya. Methods: A comparative pre- and post-test clinical trial was conducted on 40 diagnosed hypothyroid subjects. Intervention And Duration Group A received Marsha Nasya followed by Pratimarsha Nasya with Thumbi Taila. Group B received the same protocol with Amritadya Taila for 28 days (7 days Marsha, 21 days Pratimarsha). Results: Both groups showed significant improvement in TSH, Free T4, and Zulewski clinical scores, with greater reduction in Group A. Interpretation And Conclusion Nasya therapy effectively managed hypothyroidism; Thumbi Taila showed superior benefit, likely due to Vata–Kapha shamana and Agnideepana effects.