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February 19, 2026Clinical & Experimental Allergy1 citationsOpen Access

Serum Levels and Genetic Variants of CC16 : Associations With Asthma and Lung Function Development

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HKHans Jacob L. KoefoedYSYidan SunIHIlse Hugtenburg

Key Points

  • To explore the relationship between serum levels and genetic variants of CC16 with asthma and lung function development.
  • Measured serum levels of CC16 in participants
  • Analyzed genetic variants related to CC16
  • Evaluated lung function across different age groups
  • Higher serum CC16 is linked to improved lung function levels
  • Similar associations found in individuals with and without asthma
  • Growth in lung function during childhood and adolescence correlates with CC16 levels

Abstract

Summary Higher serum CC16 is associated with higher lung function levels and growth during childhood and adolescence. The association between CC16 and lung function development is similar in subjects with and without asthma.

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Cite This Study

Koefoed et al. (2026) studied this question.

synapsesocial.com/papers/6996a898ecb39a600b3ef850https://doi.org/10.1111/cea.70258
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Relation between circulating CC16 concentrations, lung function, and development of chronic obstructive pulmonary disease across the lifespan: a prospective study2015 · 193 citations
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  3. 3Comorbidity of eczema, rhinitis, and asthma in IgE-sensitised and non-IgE-sensitised children in MeDALL: a population-based cohort study2014 · 335 citations
  4. 4CC16: A Biomarker of Pollutant Exposure and Future Lung Disease?2019 · 6 citations
  5. 5Club cell secretory protein and lung function in children with cystic fibrosis2022 · 23 citations