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February 19, 2026Organic Chemistry Frontiers1 citations

Palladium-Catalyzed Allylation of Stable Glycal Boronates to Access multi-Substituted C1-Glycals: en Route to the Construction of Spirocyclic Core of Benthol A

HMHong-Rao MaTLTao LiXZXiao-Qin Zhou

Key Points

  • The aim is to efficiently construct C1-allyl glycal scaffolds for use in natural products and bioactive molecules.
  • Utilized palladium-catalyzed reactions
  • Employed stable glycal boronates as substrates
  • Focused on multi-substituted C1-glycals synthesis
  • Successfully synthesized multi-substituted C1-glycals
  • Developed a new pathway for constructing spirocyclic cores
  • Showed improved efficiency compared to previous methods

Abstract

C1-allyl glycal belongs to one type of structural motif prevailing in numerous natural products and bioactive molecules, however the efficient construction of this scaffold was less developed. In this study,...

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Cite This Study

Ma et al. (2026) studied this question.

synapsesocial.com/papers/6996a957ecb39a600b3f050bhttps://doi.org/10.1039/d6qo00107f
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