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February 20, 2026Cancer Immunology Research

Abstract C034: Epithelial alarmins coordinate type 2 immunity in colorectal cancer

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Authors

TTThornton W. ThompsonSOShealyn O'ConnorDBDebarati Bhadury

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Overview

Investigates type 2 immunity activation in colorectal cancer, revealing implications for immunotherapy.

Key Points

  • The aim is to understand how type 2 immunity operates and is regulated in colorectal cancer.
  • Used spontaneous mouse tumor models and human scRNA-seq data.
  • Investigated IL-13 production by mast cells and ILC2s in colorectal tumors.
  • Assessed epithelial signals affecting mast cell and ILC2 activation.
  • Found that CRC tumors exhibit a type 2-polarized microenvironment driven by IL-13.
  • Identified mast cells as a primary source of IL-13 in most colorectal cancers.
  • Disruption of the IL-33/ST2-MC axis reduced tumor type 2 polarization.

Cite This Study

Thompson et al. (2026) studied this question.

synapsesocial.com/papers/6997fa6dad1d9b11b3453a85https://doi.org/10.1158/2326-6074.io2026-c034
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 2799: Tumoral IL-33/ST2 signaling drives immune escape through reduced antigen presentation2026
  2. 2Abstract 6678: Microbial regulation of anti-tumor immunity in colorectal cancer2024
  3. 3IL-1R2 promotes tumorigenesis and modulates the tumor immune microenvironment in colorectal cancer2025 · 2 citations
  4. 4Abstract 1385: Crosstalk between hepatocyte and myeloid-specific IL17 signaling in colorectal cancer metastasis2024
  5. 5Abstract 5492: Spatial organization and cellular composition of immunity hubs in human colorectal cancer2024