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Synapse
February 21, 2026Current Treatment Options in Pediatrics0 citationsOpen Access

Diagnosis and Management of the Undescended Testicle: A Modern Update on Cryptorchidism for the Primary Care Clinician

MMManahil MalikTTThisha ThiagarajanMHMaedot A. Haymete

Key Points

  • The review aims to equip primary care clinicians with updated guidelines for diagnosing and treating cryptorchidism.
  • Conducted a literature review on current management guidelines for cryptorchidism.
  • Emphasized the importance of physical examination for undescended testicles.
  • Recommended urgent evaluation for congenital adrenal hyperplasia in cases with bilateral undescended testicles.
  • Outlined referral protocols for boys with unilateral undescended testicles.
  • Identified that undescended testicles occur in 3% of term males, with higher rates in preterm males.
  • Stressed the need for early intervention to preserve fertility and reduce malignancy risks.
  • Confirmed that routine imaging is not required in evaluating these cases.

Abstract

Cryptorchidism affects 3% of term and a higher percentage of per-term males. Undescended testicles present in a variety of ways and have impact on fertility potential and malignancy risk. The purpose of this review is to provide the primary care provider with an update on current guideline-based management of cryptorchidism and will serve as an all-in-one resource for optimized care. The initial evaluation of cryptorchidism centered on a nuanced physical exam. Newborn phenotypic boys with bilateral undescended testicles should be evaluated urgently for congenital adrenal hyperplasia and followed with hormone evaluation. There is no role for imaging in the routine workup of boys with an undescended testicle. Cryptorchidism is a common and treatable condition. Boys with unilateral undescended testicles should be referred to a pediatric urologist for intervention as early as 6 months to preserve fertility potential and reduce malignancy risk. Boys with descended testicles at birth require annual genital exams to monitor for secondary or acquired ascent.

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Cite This Study

Malik et al. (2026) studied this question.

synapsesocial.com/papers/69994ba9873532290d01fcddhttps://doi.org/10.1007/s40746-026-00365-9
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pre- and postoperative status of gonadotropins (FSH and LH) and inhibin-B in relation to testicular histopathology at orchiopexy in infant boys with unilateral undescended testes2014 · 30 citations
  2. 2Prevalence and Natural History of Cryptorchidism1993 · 456 citations
  3. 3Natural course of acquired undescended testis in boys2003 · 49 citations
  4. 4Malignancy Yield of Testis Pathology in Older Boys and Adolescents with Cryptorchidism2021 · 14 citations
  5. 5On the descent of the epididymo-testicular unit, cryptorchidism, and prevention of infertility2017 · 61 citations