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February 22, 2026Cureus0 citationsOpen Access

Beyond Common Arrhythmias: Discovering Brugada Syndrome in a Patient With Nonspecific Symptoms

NCNoel George CherianGulf Medical UniversitySRSrinivasan Ravindranath

Key Result

Implantable cardioverter-defibrillator placement was advised for a 48-year-old Filipino man with recurrent syncope and spontaneous type 1 Brugada ECG pattern to prevent sudden cardiac death.

Key Points

  • The aim is to highlight the diagnosis of Brugada syndrome in a patient with unclear symptoms.
  • Case report of a 48-year-old Filipino man
  • Assessment of clinical symptoms and family history
  • Use of electrocardiography to identify Brugada pattern
  • Echocardiography to assess heart structure
  • Recommendation for implantable cardioverter-defibrillator placement
  • Patient exhibited a spontaneous type 1 Brugada pattern on ECG
  • Mild left ventricular hypertrophy was identified via echocardiography
  • Normal findings in physical examination and cardiac biomarkers
  • Negative exercise stress testing for ischemia

Study Design

Type

Case Report (n=1)

Multicenter

No

Structured PICO

P
Population
1 48-year-old Filipino man with a history of recurrent syncope, presenting with persistent upper respiratory symptoms and intermittent atypical chest pain.
I
Intervention
Implantable cardioverter-defibrillator (ICD) placement and lifestyle modifications

This case highlights the critical importance of recognizing spontaneous type 1 Brugada ECG patterns in patients presenting with nonspecific symptoms but a history of syncope, enabling appropriate risk stratification and life-saving ICD placement.

Limitations

  • Single patient case report limits generalizability.
  • No genetic testing was performed to confirm SCN5A mutation due to limited availability.
  • No long-term follow-up data provided on ICD efficacy or patient outcomes.
  • No control group or comparative data presented.
  • Genetic testing was not performed due to its limited availability in the clinic.

Abstract

Brugada syndrome is an inherited cardiac channelopathy associated with life-threatening ventricular arrhythmias and sudden cardiac death and is often detected incidentally. We report a 48-year-old Filipino man who presented with persistent upper respiratory symptoms and intermittent atypical chest pain, with a history of recurrent syncope. Physical examination and cardiac biomarkers were normal. Electrocardiography revealed a spontaneous type 1 Brugada pattern in leads V2-V3. Echocardiography showed mild left ventricular hypertrophy, and exercise stress testing was negative for ischemia. Based on clinical and electrocardiographic findings, implantable cardioverter-defibrillator placement was advised. This case emphasizes the importance of recognizing Brugada syndrome in patients presenting with nonspecific symptoms to enable timely diagnosis and appropriate risk stratification.

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Cite This Study

Cherian et al. (2026) conducted a case report in Middle-aged Filipino male (48 years) with history of recurrent syncope, mild hyperlipidemia, presenting with nonspecific symptoms (dry cough, intermittent atypical chest pain) and spontaneous type 1 Brugada ECG pattern (n=1). Implantable cardioverter-defibrillator (ICD) placement was evaluated on Prevention of potentially fatal ventricular arrhythmias and sudden cardiac death. Implantable cardioverter-defibrillator placement was advised for a 48-year-old Filipino man with recurrent syncope and spontaneous type 1 Brugada ECG pattern to prevent sudden cardiac death.

synapsesocial.com/papers/699a9d14482488d673cd2c94https://doi.org/10.7759/cureus.103952
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