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February 22, 2026Cancer Biology & Therapy0 citationsOpen Access

ENPP3 drives ccRCC progression by cGAMP hydrolysis and STING–IFN suppression

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JMJiaxing MaYWYayun WuGLGuangzheng Lin

Key Points

  • The research aims to investigate the role of ENPP3 in ccRCC progression and its potential as a therapeutic target.
  • Analyzed the function of ENPP3 in ccRCC cells under hypoxic conditions.
  • Examined the effects of ENPP3 inhibition on STING-dependent immune responses.
  • Investigated cGAMP hydrolysis as a mechanism of ENPP3's action.
  • Inhibition of ENPP3 reactivated STING pathways, enhancing anti-tumor immunity.
  • cGAMP levels increased following ENPP3 inhibition, indicating a disruption in its hydrolysis.
  • Hypoxia enhances ENPP3 expression, correlating with ccRCC progression.

Abstract

ENPP3 is a hypoxia-driven, cGAMP-targeting innate immune checkpoint in ccRCC. Its inhibition reactivates STING-dependent anti-tumor immunity, providing a strong preclinical rationale for targeting ENPP3 therapeutically.

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Cite This Study

Ma et al. (2026) studied this question.

synapsesocial.com/papers/699a9d65482488d673cd33echttps://doi.org/10.1080/15384047.2026.2632995
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